surrosurv: Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses

Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) <doi:10.1111/1467-9876.00244> with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM (Rotolo et al, 2017 <doi:10.1177/0962280217718582>).

Version: 1.1.26
Depends: R (≥ 3.5.0)
Imports: copula, eha, grDevices, lme4, MASS, Matrix, msm, mvmeta, optimx, parallel, parfm, stats, survival
Suggests: R.rsp, testthat (≥ 3.0.0)
Published: 2023-04-14
DOI: 10.32614/CRAN.package.surrosurv
Author: Federico Rotolo ORCID iD [aut], Xavier Paoletti [ctb], Marc Buyse [ctb], Tomasz Burzykowski [ctb], Stefan Michiels ORCID iD [ctb], Dan Chaltiel ORCID iD [cre]
Maintainer: Dan Chaltiel <dan.chaltiel at>
License: GPL-2
NeedsCompilation: no
Materials: README NEWS
CRAN checks: surrosurv results


Reference manual: surrosurv.pdf
Vignettes: Validation of time-to-event surrogate endpoints using the surrosurv package


Package source: surrosurv_1.1.26.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): surrosurv_1.1.26.tgz, r-oldrel (arm64): surrosurv_1.1.26.tgz, r-release (x86_64): surrosurv_1.1.26.tgz, r-oldrel (x86_64): surrosurv_1.1.26.tgz
Old sources: surrosurv archive


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